Load scripts: loads libraries and useful scripts used in the analyses; all .R files contained in scripts at the root of the factory are automatically loaded
Load data: imports datasets, and may contain some ad hoc changes to the data such as specific data cleaning (not used in other reports), new variables used in the analyses, etc.
library(reportfactory)
library(here)
library(rio)
library(tidyverse)
library(incidence)
library(distcrete)
library(epitrix)
library(earlyR)
library(projections)
library(linelist)
library(remotes)
library(janitor)
library(kableExtra)
library(DT)
library(cyphr)
library(chngpt)
library(lubridate)
library(ggpubr)
library(ggnewscale)These scripts will load:
.R files inside /scripts/.R files inside /src/These scripts also contain routines to access the latest clean encrypted data (see next section).
We import the latest NHS pathways data:
x <- import_pathways() %>%
as_tibble()
x
## [90m# A tibble: 186,035 x 11[39m
## site_type date sex age ccg_code ccg_name count postcode nhs_region
## [3m[90m<chr>[39m[23m [3m[90m<date>[39m[23m [3m[90m<chr>[39m[23m [3m[90m<chr>[39m[23m [3m[90m<chr>[39m[23m [3m[90m<chr>[39m[23m [3m[90m<int>[39m[23m [3m[90m<chr>[39m[23m [3m[90m<chr>[39m[23m
## [90m 1[39m 111 2020-03-18 fema… miss… e380000… nhs_glo… 1 gl34fe South West
## [90m 2[39m 111 2020-03-18 fema… miss… e380001… nhs_sou… 1 ne325nn North Eas…
## [90m 3[39m 111 2020-03-18 fema… 0-18 e380000… nhs_air… 8 bd57jr North Eas…
## [90m 4[39m 111 2020-03-18 fema… 0-18 e380000… nhs_ash… 7 tn254ab South East
## [90m 5[39m 111 2020-03-18 fema… 0-18 e380000… nhs_bar… 35 rm13ae London
## [90m 6[39m 111 2020-03-18 fema… 0-18 e380000… nhs_bar… 9 n111np London
## [90m 7[39m 111 2020-03-18 fema… 0-18 e380000… nhs_bar… 11 s752py North Eas…
## [90m 8[39m 111 2020-03-18 fema… 0-18 e380000… nhs_bas… 19 ss143hg East of E…
## [90m 9[39m 111 2020-03-18 fema… 0-18 e380000… nhs_bas… 6 dn227xf North Eas…
## [90m10[39m 111 2020-03-18 fema… 0-18 e380000… nhs_bat… 9 ba25rp South West
## [90m# … with 186,025 more rows, and 2 more variables: day [3m[90m<int>[90m[23m, weekday [3m[90m<fct>[90m[23m[39mWe also import demographics data for NHS regions in England, used later in our analysis:
path <- here::here("data", "csv", "nhs_region_population_2018.csv")
nhs_region_pop <- rio::import(path) %>%
mutate(nhs_region = str_to_title(gsub("_"," ",nhs_region)))
nhs_region_pop$nhs_region <- gsub(" Of ", " of ", nhs_region_pop$nhs_region)
nhs_region_pop$nhs_region <- gsub(" And ", " and ", nhs_region_pop$nhs_region)
nhs_region_pop
## nhs_region variable value
## 1 North West 0-18 0.22538599
## 2 North East and Yorkshire 0-18 0.21876449
## 3 Midlands 0-18 0.22564656
## 4 East of England 0-18 0.22810783
## 5 London 0-18 0.23764782
## 6 South East 0-18 0.22458811
## 7 South West 0-18 0.20799797
## 8 North West 19-69 0.64274078
## 9 North East and Yorkshire 19-69 0.64437753
## 10 Midlands 19-69 0.63876675
## 11 East of England 19-69 0.63034229
## 12 London 19-69 0.67820084
## 13 South East 19-69 0.63267336
## 14 South West 19-69 0.63176131
## 15 North West 70-120 0.13187323
## 16 North East and Yorkshire 70-120 0.13685797
## 17 Midlands 70-120 0.13558669
## 18 East of England 70-120 0.14154988
## 19 London 70-120 0.08415135
## 20 South East 70-120 0.14273853
## 21 South West 70-120 0.16024072Finally, we import publically available deaths per NHS region:
dth <- import_deaths() %>%
mutate(nhs_region = str_to_title(gsub("_"," ",nhs_region)))
#truncation to account for reporting delay
delay_max <- 21
dth$nhs_region <- gsub(" Of ", " of ", dth$nhs_region)
dth$nhs_region <- gsub(" And ", " and ", dth$nhs_region)
dth
## date_report nhs_region deaths
## 1 2020-03-01 East of England 0
## 2 2020-03-02 East of England 1
## 3 2020-03-03 East of England 0
## 4 2020-03-04 East of England 0
## 5 2020-03-05 East of England 0
## 6 2020-03-06 East of England 1
## 7 2020-03-07 East of England 0
## 8 2020-03-08 East of England 0
## 9 2020-03-09 East of England 1
## 10 2020-03-10 East of England 0
## 11 2020-03-11 East of England 0
## 12 2020-03-12 East of England 0
## 13 2020-03-13 East of England 1
## 14 2020-03-14 East of England 2
## 15 2020-03-15 East of England 2
## 16 2020-03-16 East of England 1
## 17 2020-03-17 East of England 1
## 18 2020-03-18 East of England 5
## 19 2020-03-19 East of England 4
## 20 2020-03-20 East of England 2
## 21 2020-03-21 East of England 11
## 22 2020-03-22 East of England 12
## 23 2020-03-23 East of England 11
## 24 2020-03-24 East of England 19
## 25 2020-03-25 East of England 26
## 26 2020-03-26 East of England 36
## 27 2020-03-27 East of England 38
## 28 2020-03-28 East of England 28
## 29 2020-03-29 East of England 43
## 30 2020-03-30 East of England 45
## 31 2020-03-31 East of England 70
## 32 2020-04-01 East of England 62
## 33 2020-04-02 East of England 65
## 34 2020-04-03 East of England 80
## 35 2020-04-04 East of England 71
## 36 2020-04-05 East of England 76
## 37 2020-04-06 East of England 71
## 38 2020-04-07 East of England 93
## 39 2020-04-08 East of England 111
## 40 2020-04-09 East of England 87
## 41 2020-04-10 East of England 74
## 42 2020-04-11 East of England 92
## 43 2020-04-12 East of England 100
## 44 2020-04-13 East of England 78
## 45 2020-04-14 East of England 61
## 46 2020-04-15 East of England 82
## 47 2020-04-16 East of England 74
## 48 2020-04-17 East of England 86
## 49 2020-04-18 East of England 64
## 50 2020-04-19 East of England 67
## 51 2020-04-20 East of England 67
## 52 2020-04-21 East of England 75
## 53 2020-04-22 East of England 67
## 54 2020-04-23 East of England 49
## 55 2020-04-24 East of England 66
## 56 2020-04-25 East of England 54
## 57 2020-04-26 East of England 48
## 58 2020-04-27 East of England 46
## 59 2020-04-28 East of England 58
## 60 2020-04-29 East of England 32
## 61 2020-04-30 East of England 45
## 62 2020-05-01 East of England 49
## 63 2020-05-02 East of England 29
## 64 2020-05-03 East of England 41
## 65 2020-05-04 East of England 19
## 66 2020-05-05 East of England 36
## 67 2020-05-06 East of England 31
## 68 2020-05-07 East of England 33
## 69 2020-05-08 East of England 33
## 70 2020-05-09 East of England 29
## 71 2020-05-10 East of England 22
## 72 2020-05-11 East of England 18
## 73 2020-05-12 East of England 21
## 74 2020-05-13 East of England 27
## 75 2020-05-14 East of England 26
## 76 2020-05-15 East of England 19
## 77 2020-05-16 East of England 26
## 78 2020-05-17 East of England 17
## 79 2020-05-18 East of England 25
## 80 2020-05-19 East of England 15
## 81 2020-05-20 East of England 26
## 82 2020-05-21 East of England 21
## 83 2020-05-22 East of England 13
## 84 2020-05-23 East of England 12
## 85 2020-05-24 East of England 17
## 86 2020-05-25 East of England 25
## 87 2020-05-26 East of England 14
## 88 2020-05-27 East of England 12
## 89 2020-05-28 East of England 17
## 90 2020-05-29 East of England 16
## 91 2020-05-30 East of England 9
## 92 2020-05-31 East of England 8
## 93 2020-06-01 East of England 17
## 94 2020-06-02 East of England 14
## 95 2020-06-03 East of England 10
## 96 2020-06-04 East of England 7
## 97 2020-06-05 East of England 14
## 98 2020-06-06 East of England 5
## 99 2020-06-07 East of England 9
## 100 2020-06-08 East of England 7
## 101 2020-06-09 East of England 6
## 102 2020-06-10 East of England 8
## 103 2020-06-11 East of England 1
## 104 2020-06-12 East of England 9
## 105 2020-06-13 East of England 5
## 106 2020-06-14 East of England 4
## 107 2020-06-15 East of England 8
## 108 2020-06-16 East of England 3
## 109 2020-06-17 East of England 7
## 110 2020-06-18 East of England 4
## 111 2020-06-19 East of England 7
## 112 2020-06-20 East of England 4
## 113 2020-06-21 East of England 3
## 114 2020-06-22 East of England 6
## 115 2020-06-23 East of England 5
## 116 2020-06-24 East of England 4
## 117 2020-06-25 East of England 1
## 118 2020-06-26 East of England 5
## 119 2020-06-27 East of England 6
## 120 2020-06-28 East of England 8
## 121 2020-06-29 East of England 4
## 122 2020-06-30 East of England 5
## 123 2020-07-01 East of England 2
## 124 2020-07-02 East of England 5
## 125 2020-07-03 East of England 0
## 126 2020-07-04 East of England 3
## 127 2020-07-05 East of England 1
## 128 2020-07-06 East of England 2
## 129 2020-07-07 East of England 2
## 130 2020-07-08 East of England 0
## 131 2020-07-09 East of England 8
## 132 2020-07-10 East of England 4
## 133 2020-07-11 East of England 2
## 134 2020-07-12 East of England 1
## 135 2020-07-13 East of England 7
## 136 2020-07-14 East of England 2
## 137 2020-07-15 East of England 0
## 138 2020-07-16 East of England 0
## 139 2020-07-17 East of England 0
## 140 2020-07-18 East of England 0
## 141 2020-07-19 East of England 1
## 142 2020-07-20 East of England 1
## 143 2020-07-21 East of England 0
## 144 2020-07-22 East of England 0
## 145 2020-03-01 London 0
## 146 2020-03-02 London 0
## 147 2020-03-03 London 0
## 148 2020-03-04 London 0
## 149 2020-03-05 London 0
## 150 2020-03-06 London 1
## 151 2020-03-07 London 0
## 152 2020-03-08 London 0
## 153 2020-03-09 London 1
## 154 2020-03-10 London 0
## 155 2020-03-11 London 5
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## 157 2020-03-13 London 10
## 158 2020-03-14 London 13
## 159 2020-03-15 London 9
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## 161 2020-03-17 London 23
## 162 2020-03-18 London 27
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## 168 2020-03-24 London 86
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## 171 2020-03-27 London 129
## 172 2020-03-28 London 122
## 173 2020-03-29 London 145
## 174 2020-03-30 London 149
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## 178 2020-04-03 London 196
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## 185 2020-04-10 London 170
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## 191 2020-04-16 London 140
## 192 2020-04-17 London 100
## 193 2020-04-18 London 101
## 194 2020-04-19 London 103
## 195 2020-04-20 London 95
## 196 2020-04-21 London 94
## 197 2020-04-22 London 109
## 198 2020-04-23 London 77
## 199 2020-04-24 London 71
## 200 2020-04-25 London 58
## 201 2020-04-26 London 53
## 202 2020-04-27 London 51
## 203 2020-04-28 London 44
## 204 2020-04-29 London 45
## 205 2020-04-30 London 40
## 206 2020-05-01 London 41
## 207 2020-05-02 London 41
## 208 2020-05-03 London 36
## 209 2020-05-04 London 30
## 210 2020-05-05 London 25
## 211 2020-05-06 London 37
## 212 2020-05-07 London 37
## 213 2020-05-08 London 30
## 214 2020-05-09 London 23
## 215 2020-05-10 London 26
## 216 2020-05-11 London 18
## 217 2020-05-12 London 18
## 218 2020-05-13 London 17
## 219 2020-05-14 London 20
## 220 2020-05-15 London 18
## 221 2020-05-16 London 14
## 222 2020-05-17 London 15
## 223 2020-05-18 London 10
## 224 2020-05-19 London 14
## 225 2020-05-20 London 19
## 226 2020-05-21 London 12
## 227 2020-05-22 London 10
## 228 2020-05-23 London 6
## 229 2020-05-24 London 7
## 230 2020-05-25 London 9
## 231 2020-05-26 London 13
## 232 2020-05-27 London 7
## 233 2020-05-28 London 8
## 234 2020-05-29 London 7
## 235 2020-05-30 London 12
## 236 2020-05-31 London 6
## 237 2020-06-01 London 10
## 238 2020-06-02 London 8
## 239 2020-06-03 London 6
## 240 2020-06-04 London 8
## 241 2020-06-05 London 4
## 242 2020-06-06 London 0
## 243 2020-06-07 London 5
## 244 2020-06-08 London 5
## 245 2020-06-09 London 4
## 246 2020-06-10 London 7
## 247 2020-06-11 London 5
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## 250 2020-06-14 London 3
## 251 2020-06-15 London 1
## 252 2020-06-16 London 2
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## 254 2020-06-18 London 2
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## 256 2020-06-20 London 3
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## 261 2020-06-25 London 3
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## 290 2020-03-02 Midlands 0
## 291 2020-03-03 Midlands 1
## 292 2020-03-04 Midlands 0
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## 295 2020-03-07 Midlands 0
## 296 2020-03-08 Midlands 2
## 297 2020-03-09 Midlands 1
## 298 2020-03-10 Midlands 0
## 299 2020-03-11 Midlands 2
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## 301 2020-03-13 Midlands 5
## 302 2020-03-14 Midlands 4
## 303 2020-03-15 Midlands 5
## 304 2020-03-16 Midlands 11
## 305 2020-03-17 Midlands 8
## 306 2020-03-18 Midlands 13
## 307 2020-03-19 Midlands 8
## 308 2020-03-20 Midlands 28
## 309 2020-03-21 Midlands 13
## 310 2020-03-22 Midlands 31
## 311 2020-03-23 Midlands 33
## 312 2020-03-24 Midlands 41
## 313 2020-03-25 Midlands 48
## 314 2020-03-26 Midlands 64
## 315 2020-03-27 Midlands 72
## 316 2020-03-28 Midlands 89
## 317 2020-03-29 Midlands 92
## 318 2020-03-30 Midlands 90
## 319 2020-03-31 Midlands 123
## 320 2020-04-01 Midlands 140
## 321 2020-04-02 Midlands 142
## 322 2020-04-03 Midlands 124
## 323 2020-04-04 Midlands 151
## 324 2020-04-05 Midlands 164
## 325 2020-04-06 Midlands 140
## 326 2020-04-07 Midlands 123
## 327 2020-04-08 Midlands 186
## 328 2020-04-09 Midlands 139
## 329 2020-04-10 Midlands 127
## 330 2020-04-11 Midlands 142
## 331 2020-04-12 Midlands 139
## 332 2020-04-13 Midlands 120
## 333 2020-04-14 Midlands 116
## 334 2020-04-15 Midlands 147
## 335 2020-04-16 Midlands 102
## 336 2020-04-17 Midlands 118
## 337 2020-04-18 Midlands 115
## 338 2020-04-19 Midlands 92
## 339 2020-04-20 Midlands 107
## 340 2020-04-21 Midlands 86
## 341 2020-04-22 Midlands 78
## 342 2020-04-23 Midlands 103
## 343 2020-04-24 Midlands 79
## 344 2020-04-25 Midlands 72
## 345 2020-04-26 Midlands 81
## 346 2020-04-27 Midlands 74
## 347 2020-04-28 Midlands 68
## 348 2020-04-29 Midlands 53
## 349 2020-04-30 Midlands 56
## 350 2020-05-01 Midlands 64
## 351 2020-05-02 Midlands 51
## 352 2020-05-03 Midlands 52
## 353 2020-05-04 Midlands 61
## 354 2020-05-05 Midlands 59
## 355 2020-05-06 Midlands 59
## 356 2020-05-07 Midlands 48
## 357 2020-05-08 Midlands 34
## 358 2020-05-09 Midlands 37
## 359 2020-05-10 Midlands 42
## 360 2020-05-11 Midlands 33
## 361 2020-05-12 Midlands 45
## 362 2020-05-13 Midlands 40
## 363 2020-05-14 Midlands 38
## 364 2020-05-15 Midlands 40
## 365 2020-05-16 Midlands 34
## 366 2020-05-17 Midlands 31
## 367 2020-05-18 Midlands 36
## 368 2020-05-19 Midlands 35
## 369 2020-05-20 Midlands 36
## 370 2020-05-21 Midlands 32
## 371 2020-05-22 Midlands 27
## 372 2020-05-23 Midlands 34
## 373 2020-05-24 Midlands 20
## 374 2020-05-25 Midlands 26
## 375 2020-05-26 Midlands 33
## 376 2020-05-27 Midlands 29
## 377 2020-05-28 Midlands 28
## 378 2020-05-29 Midlands 20
## 379 2020-05-30 Midlands 21
## 380 2020-05-31 Midlands 22
## 381 2020-06-01 Midlands 20
## 382 2020-06-02 Midlands 22
## 383 2020-06-03 Midlands 24
## 384 2020-06-04 Midlands 16
## 385 2020-06-05 Midlands 21
## 386 2020-06-06 Midlands 20
## 387 2020-06-07 Midlands 17
## 388 2020-06-08 Midlands 16
## 389 2020-06-09 Midlands 18
## 390 2020-06-10 Midlands 15
## 391 2020-06-11 Midlands 13
## 392 2020-06-12 Midlands 12
## 393 2020-06-13 Midlands 6
## 394 2020-06-14 Midlands 18
## 395 2020-06-15 Midlands 12
## 396 2020-06-16 Midlands 15
## 397 2020-06-17 Midlands 11
## 398 2020-06-18 Midlands 15
## 399 2020-06-19 Midlands 10
## 400 2020-06-20 Midlands 15
## 401 2020-06-21 Midlands 14
## 402 2020-06-22 Midlands 14
## 403 2020-06-23 Midlands 16
## 404 2020-06-24 Midlands 15
## 405 2020-06-25 Midlands 18
## 406 2020-06-26 Midlands 5
## 407 2020-06-27 Midlands 5
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## 409 2020-06-29 Midlands 6
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## 413 2020-07-03 Midlands 3
## 414 2020-07-04 Midlands 4
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## 416 2020-07-06 Midlands 5
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## 423 2020-07-13 Midlands 1
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## 426 2020-07-16 Midlands 2
## 427 2020-07-17 Midlands 1
## 428 2020-07-18 Midlands 2
## 429 2020-07-19 Midlands 3
## 430 2020-07-20 Midlands 1
## 431 2020-07-21 Midlands 0
## 432 2020-07-22 Midlands 0
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## 434 2020-03-02 North East and Yorkshire 0
## 435 2020-03-03 North East and Yorkshire 0
## 436 2020-03-04 North East and Yorkshire 0
## 437 2020-03-05 North East and Yorkshire 0
## 438 2020-03-06 North East and Yorkshire 0
## 439 2020-03-07 North East and Yorkshire 0
## 440 2020-03-08 North East and Yorkshire 0
## 441 2020-03-09 North East and Yorkshire 0
## 442 2020-03-10 North East and Yorkshire 0
## 443 2020-03-11 North East and Yorkshire 0
## 444 2020-03-12 North East and Yorkshire 0
## 445 2020-03-13 North East and Yorkshire 0
## 446 2020-03-14 North East and Yorkshire 0
## 447 2020-03-15 North East and Yorkshire 2
## 448 2020-03-16 North East and Yorkshire 3
## 449 2020-03-17 North East and Yorkshire 1
## 450 2020-03-18 North East and Yorkshire 2
## 451 2020-03-19 North East and Yorkshire 6
## 452 2020-03-20 North East and Yorkshire 5
## 453 2020-03-21 North East and Yorkshire 6
## 454 2020-03-22 North East and Yorkshire 7
## 455 2020-03-23 North East and Yorkshire 9
## 456 2020-03-24 North East and Yorkshire 8
## 457 2020-03-25 North East and Yorkshire 18
## 458 2020-03-26 North East and Yorkshire 21
## 459 2020-03-27 North East and Yorkshire 28
## 460 2020-03-28 North East and Yorkshire 35
## 461 2020-03-29 North East and Yorkshire 38
## 462 2020-03-30 North East and Yorkshire 64
## 463 2020-03-31 North East and Yorkshire 60
## 464 2020-04-01 North East and Yorkshire 67
## 465 2020-04-02 North East and Yorkshire 75
## 466 2020-04-03 North East and Yorkshire 100
## 467 2020-04-04 North East and Yorkshire 105
## 468 2020-04-05 North East and Yorkshire 92
## 469 2020-04-06 North East and Yorkshire 96
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## 471 2020-04-08 North East and Yorkshire 107
## 472 2020-04-09 North East and Yorkshire 111
## 473 2020-04-10 North East and Yorkshire 117
## 474 2020-04-11 North East and Yorkshire 98
## 475 2020-04-12 North East and Yorkshire 84
## 476 2020-04-13 North East and Yorkshire 94
## 477 2020-04-14 North East and Yorkshire 107
## 478 2020-04-15 North East and Yorkshire 96
## 479 2020-04-16 North East and Yorkshire 103
## 480 2020-04-17 North East and Yorkshire 88
## 481 2020-04-18 North East and Yorkshire 95
## 482 2020-04-19 North East and Yorkshire 88
## 483 2020-04-20 North East and Yorkshire 100
## 484 2020-04-21 North East and Yorkshire 76
## 485 2020-04-22 North East and Yorkshire 84
## 486 2020-04-23 North East and Yorkshire 63
## 487 2020-04-24 North East and Yorkshire 72
## 488 2020-04-25 North East and Yorkshire 69
## 489 2020-04-26 North East and Yorkshire 65
## 490 2020-04-27 North East and Yorkshire 65
## 491 2020-04-28 North East and Yorkshire 57
## 492 2020-04-29 North East and Yorkshire 69
## 493 2020-04-30 North East and Yorkshire 57
## 494 2020-05-01 North East and Yorkshire 64
## 495 2020-05-02 North East and Yorkshire 48
## 496 2020-05-03 North East and Yorkshire 40
## 497 2020-05-04 North East and Yorkshire 49
## 498 2020-05-05 North East and Yorkshire 40
## 499 2020-05-06 North East and Yorkshire 51
## 500 2020-05-07 North East and Yorkshire 45
## 501 2020-05-08 North East and Yorkshire 42
## 502 2020-05-09 North East and Yorkshire 44
## 503 2020-05-10 North East and Yorkshire 40
## 504 2020-05-11 North East and Yorkshire 29
## 505 2020-05-12 North East and Yorkshire 27
## 506 2020-05-13 North East and Yorkshire 28
## 507 2020-05-14 North East and Yorkshire 31
## 508 2020-05-15 North East and Yorkshire 32
## 509 2020-05-16 North East and Yorkshire 35
## 510 2020-05-17 North East and Yorkshire 26
## 511 2020-05-18 North East and Yorkshire 30
## 512 2020-05-19 North East and Yorkshire 27
## 513 2020-05-20 North East and Yorkshire 22
## 514 2020-05-21 North East and Yorkshire 33
## 515 2020-05-22 North East and Yorkshire 22
## 516 2020-05-23 North East and Yorkshire 18
## 517 2020-05-24 North East and Yorkshire 26
## 518 2020-05-25 North East and Yorkshire 21
## 519 2020-05-26 North East and Yorkshire 21
## 520 2020-05-27 North East and Yorkshire 22
## 521 2020-05-28 North East and Yorkshire 21
## 522 2020-05-29 North East and Yorkshire 25
## 523 2020-05-30 North East and Yorkshire 20
## 524 2020-05-31 North East and Yorkshire 20
## 525 2020-06-01 North East and Yorkshire 17
## 526 2020-06-02 North East and Yorkshire 23
## 527 2020-06-03 North East and Yorkshire 23
## 528 2020-06-04 North East and Yorkshire 17
## 529 2020-06-05 North East and Yorkshire 18
## 530 2020-06-06 North East and Yorkshire 21
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## 533 2020-06-09 North East and Yorkshire 12
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## 536 2020-06-12 North East and Yorkshire 9
## 537 2020-06-13 North East and Yorkshire 10
## 538 2020-06-14 North East and Yorkshire 11
## 539 2020-06-15 North East and Yorkshire 9
## 540 2020-06-16 North East and Yorkshire 10
## 541 2020-06-17 North East and Yorkshire 9
## 542 2020-06-18 North East and Yorkshire 11
## 543 2020-06-19 North East and Yorkshire 6
## 544 2020-06-20 North East and Yorkshire 5
## 545 2020-06-21 North East and Yorkshire 4
## 546 2020-06-22 North East and Yorkshire 7
## 547 2020-06-23 North East and Yorkshire 7
## 548 2020-06-24 North East and Yorkshire 10
## 549 2020-06-25 North East and Yorkshire 4
## 550 2020-06-26 North East and Yorkshire 7
## 551 2020-06-27 North East and Yorkshire 3
## 552 2020-06-28 North East and Yorkshire 5
## 553 2020-06-29 North East and Yorkshire 2
## 554 2020-06-30 North East and Yorkshire 5
## 555 2020-07-01 North East and Yorkshire 1
## 556 2020-07-02 North East and Yorkshire 4
## 557 2020-07-03 North East and Yorkshire 4
## 558 2020-07-04 North East and Yorkshire 4
## 559 2020-07-05 North East and Yorkshire 2
## 560 2020-07-06 North East and Yorkshire 2
## 561 2020-07-07 North East and Yorkshire 3
## 562 2020-07-08 North East and Yorkshire 3
## 563 2020-07-09 North East and Yorkshire 0
## 564 2020-07-10 North East and Yorkshire 3
## 565 2020-07-11 North East and Yorkshire 1
## 566 2020-07-12 North East and Yorkshire 4
## 567 2020-07-13 North East and Yorkshire 1
## 568 2020-07-14 North East and Yorkshire 1
## 569 2020-07-15 North East and Yorkshire 2
## 570 2020-07-16 North East and Yorkshire 2
## 571 2020-07-17 North East and Yorkshire 1
## 572 2020-07-18 North East and Yorkshire 2
## 573 2020-07-19 North East and Yorkshire 2
## 574 2020-07-20 North East and Yorkshire 1
## 575 2020-07-21 North East and Yorkshire 1
## 576 2020-07-22 North East and Yorkshire 1
## 577 2020-03-01 North West 0
## 578 2020-03-02 North West 0
## 579 2020-03-03 North West 0
## 580 2020-03-04 North West 0
## 581 2020-03-05 North West 1
## 582 2020-03-06 North West 0
## 583 2020-03-07 North West 0
## 584 2020-03-08 North West 1
## 585 2020-03-09 North West 0
## 586 2020-03-10 North West 0
## 587 2020-03-11 North West 0
## 588 2020-03-12 North West 2
## 589 2020-03-13 North West 3
## 590 2020-03-14 North West 1
## 591 2020-03-15 North West 4
## 592 2020-03-16 North West 2
## 593 2020-03-17 North West 4
## 594 2020-03-18 North West 6
## 595 2020-03-19 North West 7
## 596 2020-03-20 North West 10
## 597 2020-03-21 North West 11
## 598 2020-03-22 North West 13
## 599 2020-03-23 North West 15
## 600 2020-03-24 North West 21
## 601 2020-03-25 North West 21
## 602 2020-03-26 North West 29
## 603 2020-03-27 North West 36
## 604 2020-03-28 North West 28
## 605 2020-03-29 North West 46
## 606 2020-03-30 North West 67
## 607 2020-03-31 North West 52
## 608 2020-04-01 North West 86
## 609 2020-04-02 North West 96
## 610 2020-04-03 North West 95
## 611 2020-04-04 North West 98
## 612 2020-04-05 North West 102
## 613 2020-04-06 North West 100
## 614 2020-04-07 North West 135
## 615 2020-04-08 North West 127
## 616 2020-04-09 North West 119
## 617 2020-04-10 North West 117
## 618 2020-04-11 North West 138
## 619 2020-04-12 North West 125
## 620 2020-04-13 North West 129
## 621 2020-04-14 North West 131
## 622 2020-04-15 North West 114
## 623 2020-04-16 North West 135
## 624 2020-04-17 North West 98
## 625 2020-04-18 North West 113
## 626 2020-04-19 North West 71
## 627 2020-04-20 North West 83
## 628 2020-04-21 North West 76
## 629 2020-04-22 North West 86
## 630 2020-04-23 North West 85
## 631 2020-04-24 North West 66
## 632 2020-04-25 North West 66
## 633 2020-04-26 North West 55
## 634 2020-04-27 North West 54
## 635 2020-04-28 North West 57
## 636 2020-04-29 North West 63
## 637 2020-04-30 North West 59
## 638 2020-05-01 North West 45
## 639 2020-05-02 North West 56
## 640 2020-05-03 North West 55
## 641 2020-05-04 North West 48
## 642 2020-05-05 North West 48
## 643 2020-05-06 North West 44
## 644 2020-05-07 North West 49
## 645 2020-05-08 North West 42
## 646 2020-05-09 North West 31
## 647 2020-05-10 North West 42
## 648 2020-05-11 North West 35
## 649 2020-05-12 North West 38
## 650 2020-05-13 North West 25
## 651 2020-05-14 North West 26
## 652 2020-05-15 North West 33
## 653 2020-05-16 North West 32
## 654 2020-05-17 North West 24
## 655 2020-05-18 North West 31
## 656 2020-05-19 North West 35
## 657 2020-05-20 North West 27
## 658 2020-05-21 North West 27
## 659 2020-05-22 North West 26
## 660 2020-05-23 North West 31
## 661 2020-05-24 North West 26
## 662 2020-05-25 North West 31
## 663 2020-05-26 North West 27
## 664 2020-05-27 North West 27
## 665 2020-05-28 North West 28
## 666 2020-05-29 North West 20
## 667 2020-05-30 North West 19
## 668 2020-05-31 North West 13
## 669 2020-06-01 North West 12
## 670 2020-06-02 North West 27
## 671 2020-06-03 North West 22
## 672 2020-06-04 North West 22
## 673 2020-06-05 North West 16
## 674 2020-06-06 North West 26
## 675 2020-06-07 North West 20
## 676 2020-06-08 North West 23
## 677 2020-06-09 North West 17
## 678 2020-06-10 North West 16
## 679 2020-06-11 North West 16
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## 681 2020-06-13 North West 10
## 682 2020-06-14 North West 15
## 683 2020-06-15 North West 16
## 684 2020-06-16 North West 15
## 685 2020-06-17 North West 13
## 686 2020-06-18 North West 14
## 687 2020-06-19 North West 7
## 688 2020-06-20 North West 11
## 689 2020-06-21 North West 8
## 690 2020-06-22 North West 11
## 691 2020-06-23 North West 13
## 692 2020-06-24 North West 13
## 693 2020-06-25 North West 15
## 694 2020-06-26 North West 6
## 695 2020-06-27 North West 7
## 696 2020-06-28 North West 9
## 697 2020-06-29 North West 9
## 698 2020-06-30 North West 7
## 699 2020-07-01 North West 3
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## 702 2020-07-04 North West 4
## 703 2020-07-05 North West 6
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## 705 2020-07-07 North West 8
## 706 2020-07-08 North West 5
## 707 2020-07-09 North West 10
## 708 2020-07-10 North West 2
## 709 2020-07-11 North West 4
## 710 2020-07-12 North West 0
## 711 2020-07-13 North West 6
## 712 2020-07-14 North West 4
## 713 2020-07-15 North West 5
## 714 2020-07-16 North West 2
## 715 2020-07-17 North West 4
## 716 2020-07-18 North West 2
## 717 2020-07-19 North West 1
## 718 2020-07-20 North West 0
## 719 2020-07-21 North West 0
## 720 2020-07-22 North West 0
## 721 2020-03-01 South East 0
## 722 2020-03-02 South East 0
## 723 2020-03-03 South East 1
## 724 2020-03-04 South East 0
## 725 2020-03-05 South East 1
## 726 2020-03-06 South East 0
## 727 2020-03-07 South East 0
## 728 2020-03-08 South East 1
## 729 2020-03-09 South East 1
## 730 2020-03-10 South East 1
## 731 2020-03-11 South East 1
## 732 2020-03-12 South East 0
## 733 2020-03-13 South East 1
## 734 2020-03-14 South East 1
## 735 2020-03-15 South East 5
## 736 2020-03-16 South East 8
## 737 2020-03-17 South East 7
## 738 2020-03-18 South East 10
## 739 2020-03-19 South East 9
## 740 2020-03-20 South East 13
## 741 2020-03-21 South East 7
## 742 2020-03-22 South East 25
## 743 2020-03-23 South East 20
## 744 2020-03-24 South East 22
## 745 2020-03-25 South East 29
## 746 2020-03-26 South East 35
## 747 2020-03-27 South East 34
## 748 2020-03-28 South East 36
## 749 2020-03-29 South East 55
## 750 2020-03-30 South East 58
## 751 2020-03-31 South East 65
## 752 2020-04-01 South East 66
## 753 2020-04-02 South East 55
## 754 2020-04-03 South East 72
## 755 2020-04-04 South East 80
## 756 2020-04-05 South East 82
## 757 2020-04-06 South East 88
## 758 2020-04-07 South East 100
## 759 2020-04-08 South East 83
## 760 2020-04-09 South East 104
## 761 2020-04-10 South East 88
## 762 2020-04-11 South East 88
## 763 2020-04-12 South East 88
## 764 2020-04-13 South East 84
## 765 2020-04-14 South East 65
## 766 2020-04-15 South East 72
## 767 2020-04-16 South East 56
## 768 2020-04-17 South East 86
## 769 2020-04-18 South East 57
## 770 2020-04-19 South East 70
## 771 2020-04-20 South East 87
## 772 2020-04-21 South East 51
## 773 2020-04-22 South East 54
## 774 2020-04-23 South East 57
## 775 2020-04-24 South East 64
## 776 2020-04-25 South East 51
## 777 2020-04-26 South East 51
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## 779 2020-04-28 South East 40
## 780 2020-04-29 South East 47
## 781 2020-04-30 South East 29
## 782 2020-05-01 South East 37
## 783 2020-05-02 South East 36
## 784 2020-05-03 South East 17
## 785 2020-05-04 South East 35
## 786 2020-05-05 South East 29
## 787 2020-05-06 South East 25
## 788 2020-05-07 South East 27
## 789 2020-05-08 South East 26
## 790 2020-05-09 South East 28
## 791 2020-05-10 South East 19
## 792 2020-05-11 South East 25
## 793 2020-05-12 South East 27
## 794 2020-05-13 South East 18
## 795 2020-05-14 South East 32
## 796 2020-05-15 South East 25
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## 841 2020-06-29 South East 5
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## 847 2020-07-05 South East 4
## 848 2020-07-06 South East 3
## 849 2020-07-07 South East 6
## 850 2020-07-08 South East 3
## 851 2020-07-09 South East 7
## 852 2020-07-10 South East 3
## 853 2020-07-11 South East 2
## 854 2020-07-12 South East 4
## 855 2020-07-13 South East 4
## 856 2020-07-14 South East 4
## 857 2020-07-15 South East 4
## 858 2020-07-16 South East 3
## 859 2020-07-17 South East 1
## 860 2020-07-18 South East 4
## 861 2020-07-19 South East 2
## 862 2020-07-20 South East 2
## 863 2020-07-21 South East 2
## 864 2020-07-22 South East 0
## 865 2020-03-01 South West 0
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## 897 2020-04-02 South West 23
## 898 2020-04-03 South West 30
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## 901 2020-04-06 South West 34
## 902 2020-04-07 South West 39
## 903 2020-04-08 South West 47
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## 905 2020-04-10 South West 46
## 906 2020-04-11 South West 43
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## 909 2020-04-14 South West 24
## 910 2020-04-15 South West 32
## 911 2020-04-16 South West 29
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## 913 2020-04-18 South West 25
## 914 2020-04-19 South West 31
## 915 2020-04-20 South West 26
## 916 2020-04-21 South West 26
## 917 2020-04-22 South West 23
## 918 2020-04-23 South West 17
## 919 2020-04-24 South West 19
## 920 2020-04-25 South West 15
## 921 2020-04-26 South West 27
## 922 2020-04-27 South West 13
## 923 2020-04-28 South West 17
## 924 2020-04-29 South West 15
## 925 2020-04-30 South West 26
## 926 2020-05-01 South West 6
## 927 2020-05-02 South West 7
## 928 2020-05-03 South West 10
## 929 2020-05-04 South West 17
## 930 2020-05-05 South West 14
## 931 2020-05-06 South West 19
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## 933 2020-05-08 South West 6
## 934 2020-05-09 South West 11
## 935 2020-05-10 South West 5
## 936 2020-05-11 South West 8
## 937 2020-05-12 South West 7
## 938 2020-05-13 South West 7
## 939 2020-05-14 South West 6
## 940 2020-05-15 South West 4
## 941 2020-05-16 South West 4
## 942 2020-05-17 South West 6
## 943 2020-05-18 South West 4
## 944 2020-05-19 South West 6
## 945 2020-05-20 South West 1
## 946 2020-05-21 South West 9
## 947 2020-05-22 South West 6
## 948 2020-05-23 South West 6
## 949 2020-05-24 South West 3
## 950 2020-05-25 South West 8
## 951 2020-05-26 South West 11
## 952 2020-05-27 South West 5
## 953 2020-05-28 South West 10
## 954 2020-05-29 South West 7
## 955 2020-05-30 South West 3
## 956 2020-05-31 South West 2
## 957 2020-06-01 South West 7
## 958 2020-06-02 South West 2
## 959 2020-06-03 South West 7
## 960 2020-06-04 South West 2
## 961 2020-06-05 South West 2
## 962 2020-06-06 South West 1
## 963 2020-06-07 South West 3
## 964 2020-06-08 South West 3
## 965 2020-06-09 South West 0
## 966 2020-06-10 South West 1
## 967 2020-06-11 South West 2
## 968 2020-06-12 South West 2
## 969 2020-06-13 South West 2
## 970 2020-06-14 South West 0
## 971 2020-06-15 South West 2
## 972 2020-06-16 South West 2
## 973 2020-06-17 South West 0
## 974 2020-06-18 South West 0
## 975 2020-06-19 South West 0
## 976 2020-06-20 South West 2
## 977 2020-06-21 South West 0
## 978 2020-06-22 South West 1
## 979 2020-06-23 South West 1
## 980 2020-06-24 South West 1
## 981 2020-06-25 South West 0
## 982 2020-06-26 South West 3
## 983 2020-06-27 South West 0
## 984 2020-06-28 South West 0
## 985 2020-06-29 South West 1
## 986 2020-06-30 South West 0
## 987 2020-07-01 South West 0
## 988 2020-07-02 South West 0
## 989 2020-07-03 South West 0
## 990 2020-07-04 South West 0
## 991 2020-07-05 South West 1
## 992 2020-07-06 South West 0
## 993 2020-07-07 South West 0
## 994 2020-07-08 South West 2
## 995 2020-07-09 South West 0
## 996 2020-07-10 South West 1
## 997 2020-07-11 South West 0
## 998 2020-07-12 South West 0
## 999 2020-07-13 South West 1
## 1000 2020-07-14 South West 0
## 1001 2020-07-15 South West 0
## 1002 2020-07-16 South West 0
## 1003 2020-07-17 South West 1
## 1004 2020-07-18 South West 0
## 1005 2020-07-19 South West 0
## 1006 2020-07-20 South West 0
## 1007 2020-07-21 South West 0
## 1008 2020-07-22 South West 0We extract the completion date from the NHS Pathways file timestamp:
The completion date of the NHS Pathways data is Thursday 23 Jul 2020.
These are functions which will be used further in the analyses.
Function to estimate the generalised R-squared as the proportion of deviance explained by a given model:
## Function to calculate R2 for Poisson model
## not adjusted for model complexity but all models have the same DF here
Rsq <- function(x) {
1 - (x$deviance / x$null.deviance)
}Function to extract growth rates per region as well as halving times, and the associated 95% confidence intervals:
## function to extract the coefficients, find the level of the intercept,
## reconstruct the values of r, get confidence intervals
get_r <- function(model) {
## extract coefficients and conf int
out <- data.frame(r = coef(model)) %>%
rownames_to_column("var") %>%
cbind(confint(model)) %>%
filter(!grepl("day_of_week", var)) %>%
filter(grepl("day", var)) %>%
rename(lower_95 = "2.5 %",
upper_95 = "97.5 %") %>%
mutate(var = sub("day:", "", var))
## reconstruct values: intercept + region-coefficient
for (i in 2:nrow(out)) {
out[i, -1] <- out[1, -1] + out[i, -1]
}
## find the name of the intercept, restore regions names
out <- out %>%
mutate(nhs_region = model$xlevels$nhs_region) %>%
select(nhs_region, everything(), -var)
## find halving times
halving <- log(0.5) / out[,-1] %>%
rename(halving_t = r,
halving_t_lower_95 = lower_95,
halving_t_upper_95 = upper_95)
## set halving times with exclusion intervals to NA
no_halving <- out$lower_95 < 0 & out$upper_95 > 0
halving[no_halving, ] <- NA_real_
## return all data
cbind(out, halving)
}Functions used in the correlation analysis between NHS Pathways reports and deaths:
## Function to calculate Pearson's correlation between deaths and lagged
## reports. Note that `pearson` can be replaced with `spearman` for rank
## correlation.
getcor <- function(x, ndx) {
return(cor(x$deaths[ndx],
x$note_lag[ndx],
use = "complete.obs",
method = "pearson"))
}
## Catch if sample size throws an error
getcor2 <- possibly(getcor, otherwise = NA)
getboot <- function(x) {
result <- boot::boot.ci(boot::boot(x, getcor2, R = 1000),
type = "bca")
return(data.frame(n = sum(!is.na(x$note_lag) & !is.na(x$deaths)),
r = result$t0,
r_low = result$bca[4],
r_hi = result$bca[5]))
}Function to classify the day of the week into weekend, Monday, and the rest:
## Fn to add day of week
day_of_week <- function(df) {
df %>%
dplyr::mutate(day_of_week = lubridate::wday(date, label = TRUE)) %>%
dplyr::mutate(day_of_week = dplyr::case_when(
day_of_week %in% c("Sat", "Sun") ~ "weekend",
day_of_week %in% c("Mon") ~ "monday",
!(day_of_week %in% c("Sat", "Sun", "Mon")) ~ "rest_of_week"
) %>%
factor(levels = c("rest_of_week", "monday", "weekend")))
}Custom color palettes, color scales, and vectors of colors:
We look for temporal patterns in COVID-19 related 111/999 calls and 111 online reports. Analyses are broken down by NHS region. We also look for estimates of recent growth rate and associated doubling / halving time.
tab_date_region_all <- x %>%
filter(!is.na(nhs_region)) %>%
group_by(date, nhs_region) %>%
summarise(n = sum(count))
dth %>%
mutate(trusted = case_when(date_report < max(dth$date_report)-delay_max ~ "Y",
date_report >= max(dth$date_report)-delay_max ~ "N"),
value = "Deaths",
vline = max(dth$date_report)-delay_max-1,
lab = "Truncated for reporting delay",
lab_pos_x = vline + 10,
lab_pos_y = 150,
lab_col = "darkgrey") %>%
rename(date = date_report,
n = deaths) %>%
bind_rows(
mutate(tab_date_region_all, value = "Reports",
trusted = "Y",
vline = as.Date("2020-03-23"),
lab = "Start of UK lockdown",
lab_pos_x = vline - 8,
lab_pos_y = 30200,
lab_col = "black")
) %>%
mutate(value = factor(value, levels = c("Reports","Deaths"))) -> dths_reports
plot_dth_report <-
ggplot(dths_reports, aes(date, n, colour = nhs_region)) +
# Add main points and lines, coloured by region and fade out deaths for excluded period
geom_point(aes(alpha = trusted)) +
geom_line(alpha = 0.2) +
geom_smooth(method = "loess", span = .5, color = "black") +
scale_colour_manual("", values = pal) +
scale_alpha_manual(values = c(0.3,1)) +
guides(alpha = F) +
# Add vertical markers for important dates with labels - different for each facet
ggnewscale::new_scale_colour() +
geom_vline(aes(xintercept = vline, col = value), lty = "solid") +
geom_text(aes(x = lab_pos_x, y = lab_pos_y, label = lab, col = value), size = 3) +
scale_colour_manual("",values = c("black","darkgrey"), guide = F) +
# Facet by deaths and reports
facet_grid(rows = vars(value), scales = "free_y", switch = "y") +
# Other formatting
theme_bw() +
scale_weeks +
theme(legend.position = "bottom",strip.placement = "outside") +
rotate_x +
labs(x = NULL,
y = NULL)
plot_dth_reportWe plot the number of 111/999 calls and 111 online reports by age, and the proportion of 111/999 calls and 111 online reports by age. In the second graph, the vertical lines indicate the proportion of individuals residing in the corresponding NHS region who belong to the corresponding age group.
tab_date_region_age_all <- x %>%
filter(!is.na(nhs_region),
age != "missing") %>%
group_by(date, nhs_region, age) %>%
summarise(n = sum(count))
tab_date_region_age_all %>%
ggplot(aes(x = date, y = n, fill = age)) +
geom_col(position = "stack") +
scale_fill_manual(values = age.pal) +
theme_bw() +
scale_weeks +
theme(legend.position = "bottom",
axis.text.x = element_text(angle = 90, hjust = 1)) +
guides(fill = guide_legend(title = "Age", ncol = 3)) +
labs(x = NULL,
y = "Total daily reports by age") +
facet_wrap(~ nhs_region, ncol = 4)
tab_date_region_age_all <- tab_date_region_age_all %>%
group_by(date, nhs_region) %>%
summarise(tot = sum(n)) %>%
left_join(tab_date_region_age_all, by = c("date", "nhs_region")) %>%
mutate(prop_n = n/tot)
tab_date_region_age_all %>%
ggplot(aes(x = date, y = prop_n, color = age)) +
scale_color_manual(values = age.pal) +
geom_line() +
geom_point() +
geom_hline(data = nhs_region_pop, aes(yintercept = value, color = variable)) +
theme_bw() +
scale_weeks +
theme(legend.position = "bottom",
axis.text.x = element_text(angle = 90, hjust = 1)) +
guides(color = guide_legend(title = "Age", ncol = 3)) +
labs(x = NULL,
y = "Proportion of daily reports by age") +
facet_wrap(~ nhs_region, ncol = 4)We fit quasi-Poisson GLMs for 14-day windows to get growth rates over time.
## set moving time window (1/2/3 weeks)
w <- 14
# create empty df
r_all_sliding <- NULL
## make data for model
x_model_all_moving <- x %>%
filter(!is.na(nhs_region)) %>%
group_by(date, nhs_region) %>%
summarise(n = sum(count))
unique_dates <- unique(x_model_all_moving$date)
for (i in 1:(length(unique_dates) - w)) {
date_i <- unique_dates[i]
date_i_max <- date_i + w
model_data <- x_model_all_moving %>%
filter(date >= date_i & date < date_i_max) %>%
mutate(day = as.integer(date - date_i)) %>%
day_of_week()
mod <- glm(n ~ day * nhs_region + day_of_week,
data = model_data,
family = 'quasipoisson')
# get growth rate
r <- get_r(mod)
r$w_min <- date_i
r$w_max <- date_i_max
# combine all estimates
r_all_sliding <- bind_rows(r_all_sliding, r)
}
#serial interval distribution
SI_param = epitrix::gamma_mucv2shapescale(4.7, 2.9/4.7)
SI_distribution <- distcrete::distcrete("gamma", interval = 1,
shape = SI_param$shape,
scale = SI_param$scale,
w = 0.5)
#convert growth rates r to R0
r_all_sliding <- r_all_sliding %>%
mutate(R = epitrix::r2R0(r, SI_distribution),
R_lower_95 = epitrix::r2R0(lower_95, SI_distribution),
R_upper_95 = epitrix::r2R0(upper_95, SI_distribution))We examine the evolution of the growth rate by region over time.
# plot
plot_growth <-
r_all_sliding %>%
ggplot(aes(x = w_max, y = r)) +
geom_ribbon(aes(ymin = lower_95, ymax = upper_95, fill = nhs_region), alpha = 0.1) +
geom_line(aes(colour = nhs_region)) +
geom_point(aes(colour = nhs_region)) +
geom_hline(yintercept = 0, linetype = "dashed") +
theme_bw() +
scale_weeks +
theme(legend.position = "bottom",
plot.margin = margin(0.5,1,0.5,0.5, "cm")) +
guides(colour = guide_legend(title = "", override.aes = list(fill = NA)), fill = FALSE) +
labs(x = "",
y = "Estimated daily growth rate (r)") +
scale_colour_manual(values = pal)From the growth rate, we derive R and examine its value through time.
# plot
plot_R <-
r_all_sliding %>%
ggplot(aes(x = w_max, y = R)) +
geom_ribbon(aes(ymin = R_lower_95, ymax = R_upper_95, fill = nhs_region), alpha = 0.1) +
geom_line(aes(colour = nhs_region)) +
geom_point(aes(colour = nhs_region)) +
geom_hline(yintercept = 1, linetype = "dashed") +
theme_bw() +
scale_weeks +
theme(legend.position = "bottom",
plot.margin = margin(0.5,1,0.5,0.5, "cm")) +
guides(color = guide_legend(title = "", override.aes = list(fill = NA)), fill = FALSE) +
labs(x = "",
y = "Estimated effective reproduction\nnumber (Re)") +
scale_colour_manual(values = pal)
R <- r_all_sliding %>%
mutate(lower_95 = R_lower_95,
upper_95 = R_upper_95,
value = R,
measure = "R",
reference = 1)
r_R <- r_all_sliding %>%
mutate(measure = "r",
value = r,
reference = 0) %>%
bind_rows(R)
r_R %>%
ggplot(aes(x = w_max, y = value)) +
geom_ribbon(aes(ymin = lower_95, ymax = upper_95, fill = nhs_region), alpha = 0.1) +
geom_line(aes(colour = nhs_region)) +
geom_point(aes(colour = nhs_region)) +
geom_hline(aes(yintercept = reference), linetype = "dashed") +
theme_bw() +
scale_weeks +
rotate_x +
theme(legend.position = "bottom",
plot.margin = margin(0.5,1,0,0, "cm"),
strip.background = element_blank(),
# strip.text.x = element_blank(),
strip.placement = "outside"
) +
guides(color = guide_legend(title = "",
override.aes = list(fill = NA)),
fill = FALSE) +
labs(x = "", y = "") +
scale_colour_manual(values = pal) +
facet_grid(rows = vars(measure),
scales = "free_y",
switch = "y",
labeller = as_labeller(c(r = "Daily growth rate (r)",
R = "Effective reproduction\nnumber (Re)")))We repeat the above analysis, where we fit quasi-Poisson GLMs for 14-day windows to get growth rates over time, but apply this to each age group separately (0-18, 19-69, 70-120 years old).
We first run the analysis for 0-18 years old.
## set moving time window (2 weeks)
w <- 14
# create empty df
r_all_sliding_0_18 <- NULL
## make data for model
x_model_all_moving_0_18 <- x %>%
filter(!is.na(nhs_region),
age == "0-18") %>%
group_by(date, nhs_region) %>%
summarise(n = sum(count))
unique_dates <- unique(x_model_all_moving_0_18$date)
for (i in 1:(length(unique_dates) - w)) {
date_i <- unique_dates[i]
date_i_max <- date_i + w
model_data <- x_model_all_moving_0_18 %>%
filter(date >= date_i & date < date_i_max) %>%
mutate(day = as.integer(date - date_i)) %>%
day_of_week()
mod <- glm(n ~ day * nhs_region + day_of_week,
data = model_data,
family = 'quasipoisson')
# get growth rate
r <- get_r(mod)
r$w_min <- date_i
r$w_max <- date_i_max
# combine all estimates
r_all_sliding_0_18 <- bind_rows(r_all_sliding_0_18, r)
}
#serial interval distribution
SI_param = epitrix::gamma_mucv2shapescale(4.7, 2.9/4.7)
SI_distribution <- distcrete::distcrete("gamma", interval = 1,
shape = SI_param$shape,
scale = SI_param$scale, w = 0.5)
#convert growth rates r to R0
r_all_sliding_0_18 <- r_all_sliding_0_18 %>%
mutate(R = epitrix::r2R0(r, SI_distribution),
R_lower_95 = epitrix::r2R0(lower_95, SI_distribution),
R_upper_95 = epitrix::r2R0(upper_95, SI_distribution))# plot
plot_growth <-
r_all_sliding_0_18 %>%
ggplot(aes(x = w_max, y = r)) +
geom_ribbon(aes(ymin = lower_95, ymax = upper_95, fill = nhs_region), alpha = 0.1) +
geom_line(aes(colour = nhs_region)) +
geom_point(aes(colour = nhs_region)) +
geom_hline(yintercept = 0, linetype = "dashed") +
theme_bw() +
scale_weeks +
theme(legend.position = "bottom",
plot.margin = margin(0.5,1,0.5,0.5, "cm")) +
guides(colour = guide_legend(title = "",override.aes = list(fill = NA)), fill = FALSE) +
labs(x = "",
y = "Estimated daily growth rate (r)"
) +
scale_colour_manual(values = pal)# plot
plot_R <-
r_all_sliding_0_18 %>%
ggplot(aes(x = w_max, y = R)) +
geom_ribbon(aes(ymin = R_lower_95, ymax = R_upper_95, fill = nhs_region), alpha = 0.1) +
geom_line(aes(colour = nhs_region)) +
geom_point(aes(colour = nhs_region)) +
geom_hline(yintercept = 1, linetype = "dashed") +
theme_bw() +
scale_weeks +
theme(legend.position = "bottom",
plot.margin = margin(0.5,1,0.5,0.5, "cm")) +
guides(color = guide_legend(title = "", override.aes = list(fill = NA)), fill = FALSE) +
labs(x = "",
y = "Estimated effective reproduction\nnumber (Re)"
) +
scale_colour_manual(values = pal)
R <- r_all_sliding_0_18 %>%
mutate(lower_95 = R_lower_95,
upper_95 = R_upper_95,
value = R,
measure = "R",
reference = 1)
r_R <- r_all_sliding_0_18 %>%
mutate(measure = "r",
value = r,
reference = 0) %>%
bind_rows(R)
fig2_3_0_18 <- r_R %>%
ggplot(aes(x = w_max, y = value)) +
geom_ribbon(aes(ymin = lower_95, ymax = upper_95, fill = nhs_region), alpha = 0.1) +
geom_line(aes(colour = nhs_region)) +
geom_point(aes(colour = nhs_region)) +
geom_hline(aes(yintercept = reference), linetype = "dashed") +
theme_bw() +
scale_weeks +
theme(legend.position = "bottom",
plot.margin = margin(0.5,1,0,0, "cm"),
strip.background = element_blank(),
strip.placement = "outside"
) +
guides(color = guide_legend(title = "", override.aes = list(fill = NA)), fill = FALSE) +
labs(x = "", y = "") +
scale_colour_manual(values = pal) +
facet_grid(rows = vars(measure),
scales = "free_y",
switch = "y",
labeller = as_labeller(c(r = "Daily growth rate (r)",
R = "Effective reproduction\nnumber (Re)")))Then, we run the analysis for 19-69 years old.
## set moving time window (2 weeks)
w <- 14
# create empty df
r_all_sliding_19_69 <- NULL
## make data for model
x_model_all_moving_19_69 <- x %>%
filter(!is.na(nhs_region),
age == "19-69") %>%
group_by(date, nhs_region) %>%
summarise(n = sum(count))
unique_dates <- unique(x_model_all_moving_19_69$date)
for (i in 1:(length(unique_dates) - w)) {
date_i <- unique_dates[i]
date_i_max <- date_i + w
model_data <- x_model_all_moving_19_69 %>%
filter(date >= date_i & date < date_i_max) %>%
mutate(day = as.integer(date - date_i)) %>%
day_of_week()
mod <- glm(n ~ day * nhs_region + day_of_week,
data = model_data,
family = 'quasipoisson')
# get growth rate
r <- get_r(mod)
r$w_min <- date_i
r$w_max <- date_i_max
# combine all estimates
r_all_sliding_19_69 <- bind_rows(r_all_sliding_19_69, r)
}
#serial interval distribution
SI_param = epitrix::gamma_mucv2shapescale(4.7, 2.9/4.7)
SI_distribution <- distcrete::distcrete("gamma", interval = 1,
shape = SI_param$shape,
scale = SI_param$scale, w = 0.5)
#convert growth rates r to R0
r_all_sliding_19_69 <- r_all_sliding_19_69 %>%
mutate(R = epitrix::r2R0(r, SI_distribution),
R_lower_95 = epitrix::r2R0(lower_95, SI_distribution),
R_upper_95 = epitrix::r2R0(upper_95, SI_distribution))# plot
plot_growth <-
r_all_sliding_19_69 %>%
ggplot(aes(x = w_max, y = r)) +
geom_ribbon(aes(ymin = lower_95, ymax = upper_95, fill = nhs_region), alpha = 0.1) +
geom_line(aes(colour = nhs_region)) +
geom_point(aes(colour = nhs_region)) +
geom_hline(yintercept = 0, linetype = "dashed") +
theme_bw() +
scale_weeks +
theme(legend.position = "bottom",
plot.margin = margin(0.5,1,0.5,0.5, "cm")) +
guides(colour = guide_legend(title = "", override.aes = list(fill = NA)), fill = FALSE) +
labs(x = "",
y = "Estimated daily growth rate (r)") +
scale_colour_manual(values = pal)# plot
plot_R <-
r_all_sliding_19_69 %>%
ggplot(aes(x = w_max, y = R)) +
geom_ribbon(aes(ymin = R_lower_95, ymax = R_upper_95, fill = nhs_region), alpha = 0.1) +
geom_line(aes(colour = nhs_region)) +
geom_point(aes(colour = nhs_region)) +
geom_hline(yintercept = 1, linetype = "dashed") +
theme_bw() +
scale_weeks +
theme(legend.position = "bottom",
plot.margin = margin(0.5,1,0.5,0.5, "cm")) +
guides(color = guide_legend(title = "", override.aes = list(fill = NA)), fill = FALSE) +
labs(x = "",
y = "Estimated effective reproduction\nnumber (Re)"
) +
scale_colour_manual(values = pal)
R <- r_all_sliding_19_69 %>%
mutate(lower_95 = R_lower_95,
upper_95 = R_upper_95,
value = R,
measure = "R",
reference = 1)
r_R <- r_all_sliding_19_69 %>%
mutate(measure = "r",
value = r,
reference = 0) %>%
bind_rows(R)
fig2_3_19_69 <- r_R %>%
ggplot(aes(x = w_max, y = value)) +
geom_ribbon(aes(ymin = lower_95, ymax = upper_95, fill = nhs_region), alpha = 0.1) +
geom_line(aes(colour = nhs_region)) +
geom_point(aes(colour = nhs_region)) +
geom_hline(aes(yintercept = reference), linetype = "dashed") +
theme_bw() +
scale_weeks +
theme(legend.position = "bottom",
plot.margin = margin(0.5,1,0,0, "cm"),
strip.background = element_blank(),
strip.placement = "outside"
) +
guides(color = guide_legend(title = "", override.aes = list(fill = NA)), fill = FALSE) +
labs(x = "", y = "") +
scale_colour_manual(values = pal) +
facet_grid(rows = vars(measure),
scales = "free_y",
switch = "y",
labeller = as_labeller(c(r = "Daily growth rate (r)",
R = "Effective reproduction\nnumber (Re)")))Finally, we run the analysis for 70-120 years old.
## set moving time window (2 weeks)
w <- 14
# create empty df
r_all_sliding_70_120 <- NULL
## make data for model
x_model_all_moving_70_120 <- x %>%
filter(!is.na(nhs_region),
age == "70-120") %>%
group_by(date, nhs_region) %>%
summarise(n = sum(count))
unique_dates <- unique(x_model_all_moving_70_120$date)
for (i in 1:(length(unique_dates) - w)) {
date_i <- unique_dates[i]
date_i_max <- date_i + w
model_data <- x_model_all_moving_70_120 %>%
filter(date >= date_i & date < date_i_max) %>%
mutate(day = as.integer(date - date_i)) %>%
day_of_week()
mod <- glm(n ~ day * nhs_region + day_of_week,
data = model_data,
family = 'quasipoisson')
# get growth rate
r <- get_r(mod)
r$w_min <- date_i
r$w_max <- date_i_max
# combine all estimates
r_all_sliding_70_120 <- bind_rows(r_all_sliding_70_120, r)
}
#serial interval distribution
SI_param = epitrix::gamma_mucv2shapescale(4.7, 2.9/4.7)
SI_distribution <- distcrete::distcrete("gamma", interval = 1,
shape = SI_param$shape,
scale = SI_param$scale, w = 0.5)
#convert growth rates r to R0
r_all_sliding_70_120 <- r_all_sliding_70_120 %>%
mutate(R = epitrix::r2R0(r, SI_distribution),
R_lower_95 = epitrix::r2R0(lower_95, SI_distribution),
R_upper_95 = epitrix::r2R0(upper_95, SI_distribution))# plot
plot_growth <-
r_all_sliding_70_120 %>%
ggplot(aes(x = w_max, y = r)) +
geom_ribbon(aes(ymin = lower_95, ymax = upper_95, fill = nhs_region), alpha = 0.1) +
geom_line(aes(colour = nhs_region)) +
geom_point(aes(colour = nhs_region)) +
geom_hline(yintercept = 0, linetype = "dashed") +
theme_bw() +
scale_weeks +
theme(legend.position = "bottom",
plot.margin = margin(0.5,1,0.5,0.5, "cm")) +
guides(colour = guide_legend(title = "",override.aes = list(fill = NA)), fill = FALSE) +
labs(x = "",
y = "Estimated daily growth rate (r)"
) +
scale_colour_manual(values = pal)# plot
plot_R <-
r_all_sliding_70_120 %>%
ggplot(aes(x = w_max, y = R)) +
geom_ribbon(aes(ymin = R_lower_95, ymax = R_upper_95, fill = nhs_region), alpha = 0.1) +
geom_line(aes(colour = nhs_region)) +
geom_point(aes(colour = nhs_region)) +
geom_hline(yintercept = 1, linetype = "dashed") +
theme_bw() +
scale_weeks +
theme(legend.position = "bottom",
plot.margin = margin(0.5,1,0.5,0.5, "cm")) +
guides(color = guide_legend(title = "", override.aes = list(fill = NA)), fill = FALSE) +
labs(x = "",
y = "Estimated effective reproduction\nnumber (Re)") +
scale_colour_manual(values = pal)
R <- r_all_sliding_70_120 %>%
mutate(lower_95 = R_lower_95,
upper_95 = R_upper_95,
value = R,
measure = "R",
reference = 1)
r_R <- r_all_sliding_70_120 %>%
mutate(measure = "r",
value = r,
reference = 0) %>%
bind_rows(R)
fig2_3_70_120 <- r_R %>%
ggplot(aes(x = w_max, y = value)) +
geom_ribbon(aes(ymin = lower_95, ymax = upper_95, fill = nhs_region), alpha = 0.1) +
geom_line(aes(colour = nhs_region)) +
geom_point(aes(colour = nhs_region)) +
geom_hline(aes(yintercept = reference), linetype = "dashed") +
theme_bw() +
scale_weeks +
theme(legend.position = "bottom",
plot.margin = margin(0.5,1,0,0, "cm"),
strip.background = element_blank(),
strip.placement = "outside"
) +
guides(color = guide_legend(title = "", override.aes = list(fill = NA)), fill = FALSE) +
labs(x = "", y = "") +
scale_colour_manual(values = pal) +
facet_grid(rows = vars(measure),
scales = "free_y",
switch = "y",
labeller = as_labeller(c(r = "Daily growth rate (r)",
R = "Effective reproduction\nnumber (Re)"))) We combine the estimated growth rates and effective reproduction numbers into a single figure.
ggpubr::ggarrange(fig2_3_0_18,
fig2_3_19_69,
fig2_3_70_120,
nrow = 3,
labels = "AUTO",
common.legend = TRUE,
legend = "bottom",
align = "hv") We want to explore the correlation between NHS Pathways reports and deaths, and assess the potential for reports to be used as an early warning system for disease resurgence.
Death data are publically available. We truncate the time series to avoid bias from reporting delay - we assume a conservative delay of three weeks.
We calculate Pearson’s correlation coefficient between deaths and NHS Pathways notifications using different lags. Confidence intervals are obtained using bootstrap. Note that results were also confirmed using Spearman’s rank correlation.
First we join the NHS Pathways and death data, and aggregate over all England:
## truncate death data for reporting delay
trunc_date <- max(dth$date_report) - delay_max
dth_trunc <- dth %>%
rename(date = date_report) %>%
filter(date <= trunc_date)
## join with notification data
all_data <- x %>%
filter(!is.na(nhs_region)) %>%
group_by(date, nhs_region) %>%
summarise(count = sum(count, na.rm = T)) %>%
ungroup %>%
inner_join(dth_trunc,
by = c("date","nhs_region"))
all_tot <- all_data %>%
group_by(date) %>%
summarise(count = sum(count, na.rm = TRUE),
deaths = sum(deaths, na.rm = TRUE)) We calculate correlation with lagged NHS Pathways reports from 0 to 30 days behind deaths:
## Calculate all correlations + bootstrap CIs
lag_cor <- data.frame()
for (i in 0:30) {
## lag reports
summary <- all_tot %>%
mutate(note_lag = lag(count, i)) %>%
## calculate rank correlation and bootstrap CI
getboot(.) %>%
mutate(lag = i)
lag_cor <- bind_rows(lag_cor, summary)
}
cor_vs_lag <- ggplot(lag_cor, aes(lag, r)) +
theme_bw() +
geom_ribbon(aes(ymin = r_low, ymax = r_hi), alpha = 0.2) +
geom_hline(yintercept = 0, lty = "longdash") +
geom_point() +
geom_line() +
labs(x = "Lag between NHS pathways and death data (days)",
y = "Pearson's correlation") +
large_txt
cor_vs_lagThis analysis suggests that the best lag is 23 days. We then compare and plot the number of deaths reported against the number of NHS Pathways reports lagged by 23 days.
all_tot <- all_tot %>%
rename(date_death = date) %>%
mutate(note_lag = lag(count, lag_cor$lag[l_opt]),
note_lag_c = (note_lag - mean(note_lag, na.rm = T)),
date_note = lag(date_death,16))
lag_mod <- glm(deaths ~ note_lag, data = all_tot, family = "quasipoisson")
summary(lag_mod)
##
## Call:
## glm(formula = deaths ~ note_lag, family = "quasipoisson", data = all_tot)
##
## Deviance Residuals:
## Min 1Q Median 3Q Max
## -14.1341 -4.9640 -0.5784 3.8745 8.9805
##
## Coefficients:
## Estimate Std. Error t value Pr(>|t|)
## (Intercept) 4.520e+00 6.771e-02 66.76 <2e-16 ***
## note_lag 1.516e-05 7.063e-07 21.46 <2e-16 ***
## ---
## Signif. codes: 0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1
##
## (Dispersion parameter for quasipoisson family taken to be 27.57536)
##
## Null deviance: 13894.3 on 82 degrees of freedom
## Residual deviance: 2387.8 on 81 degrees of freedom
## (23 observations deleted due to missingness)
## AIC: NA
##
## Number of Fisher Scoring iterations: 4
exp(coefficients(lag_mod))
## (Intercept) note_lag
## 91.816148 1.000015
exp(confint(lag_mod))
## 2.5 % 97.5 %
## (Intercept) 80.225620 104.619006
## note_lag 1.000014 1.000017
Rsq(lag_mod)
## [1] 0.8281474
mod_fit <- as.data.frame(predict(lag_mod, type = "link", se.fit = TRUE)[1:2])
all_tot_pred <-
all_tot %>%
filter(!is.na(note_lag)) %>%
mutate(pred = mod_fit$fit,
pred.se = mod_fit$se.fit,
low = exp(pred - 1.96*pred.se),
hi = exp(pred + 1.96*pred.se))
glm_fit <- all_tot_pred %>%
filter(!is.na(note_lag)) %>%
ggplot(aes(x = note_lag, y = deaths)) +
geom_point() +
geom_line(aes(y = exp(pred))) +
geom_ribbon(aes(ymin = low, ymax = hi), alpha = 0.3, col = "grey") +
theme_bw() +
labs(y = "Daily number of\ndeaths reported",
x = "Daily number of NHS Pathways reports") +
large_txt
glm_fitThis is a comparison of gamma versus lognormal distribution for the serial interval used to convert r to R in our analysis. Both distributions are parameterised with mean 4.7 and standard deviation 2.9.
SI_param <- epitrix::gamma_mucv2shapescale(4.7, 2.9/4.7)
SI_distribution <- distcrete::distcrete("gamma", interval = 1,
shape = SI_param$shape,
scale = SI_param$scale, w = 0.5)
SI_distribution2 <- distcrete::distcrete("lnorm", interval = 1,
meanlog = log(4.7),
sdlog = log(2.9), w = 0.5)
SI_dist1 <- data.frame(x = SI_distribution$r(1e5))
SI_dist1 <- count(SI_dist1, x) %>%
ggplot() +
geom_col(aes(x = x, y = n)) +
labs(x = "Serial interval (days)", y = "Frequency") +
scale_x_continuous(breaks = seq(0, 30, 5)) +
theme_bw()
SI_dist2 <- data.frame(x = SI_distribution2$r(1e5))
SI_dist2 <- count(SI_dist2, x) %>%
ggplot() +
geom_col(aes(x = x, y = n)) +
labs(x = "Serial interval (days)", y = "Frequency") +
scale_x_continuous(breaks = seq(0, 200, 20), limits = c(0, 200)) +
theme_bw()
ggpubr::ggarrange(SI_dist1,
SI_dist2,
nrow = 1,
labels = "AUTO") We reproduce the window analysis with either a 7 or 21 days window for sensitivity purposes.
First with the 7 days window:
## set moving time window (1/2/3 weeks)
w <- 7
# create empty df
r_all_sliding_7days <- NULL
## make data for model
x_model_all_moving <- x %>%
filter(!is.na(nhs_region)) %>%
group_by(date, nhs_region) %>%
summarise(n = sum(count))
unique_dates <- unique(x_model_all_moving$date)
for (i in 1:(length(unique_dates) - w)) {
date_i <- unique_dates[i]
date_i_max <- date_i + w
model_data <- x_model_all_moving %>%
filter(date >= date_i & date < date_i_max) %>%
mutate(day = as.integer(date - date_i)) %>%
day_of_week()
mod <- glm(n ~ day * nhs_region + day_of_week,
data = model_data,
family = 'quasipoisson')
# get growth rate
r <- get_r(mod)
r$w_min <- date_i
r$w_max <- date_i_max
# combine all estimates
r_all_sliding_7days <- bind_rows(r_all_sliding_7days, r)
}
#serial interval distribution
SI_param = epitrix::gamma_mucv2shapescale(4.7, 2.9/4.7)
SI_distribution <- distcrete::distcrete("gamma", interval = 1,
shape = SI_param$shape,
scale = SI_param$scale,
w = 0.5)
#convert growth rates r to R0
r_all_sliding_7days <- r_all_sliding_7days %>%
mutate(R = epitrix::r2R0(r, SI_distribution),
R_lower_95 = epitrix::r2R0(lower_95, SI_distribution),
R_upper_95 = epitrix::r2R0(upper_95, SI_distribution))# plot
plot_growth <-
r_all_sliding_7days %>%
ggplot(aes(x = w_max, y = r)) +
geom_ribbon(aes(ymin = lower_95, ymax = upper_95, fill = nhs_region), alpha = 0.1) +
geom_line(aes(colour = nhs_region)) +
geom_point(aes(colour = nhs_region)) +
geom_hline(yintercept = 0, linetype = "dashed") +
theme_bw() +
scale_weeks +
theme(legend.position = "bottom",
plot.margin = margin(0.5,1,0.5,0.5, "cm")) +
guides(colour = guide_legend(title = "",override.aes = list(fill = NA)), fill = FALSE) +
labs(x = "",
y = "Estimated daily growth rate (r)") +
scale_colour_manual(values = pal)plot_R <- r_all_sliding_7days %>%
ggplot(aes(x = w_max, y = R)) +
geom_ribbon(aes(ymin = R_lower_95, ymax = R_upper_95, fill = nhs_region), alpha = 0.1) +
geom_line(aes(colour = nhs_region)) +
geom_point(aes(colour = nhs_region)) +
geom_hline(yintercept = 1, linetype = "dashed") +
theme_bw() +
scale_weeks +
theme(legend.position = "bottom",
plot.margin = margin(0.5,1,0.5,0.5, "cm")) +
guides(color = guide_legend(title = "", override.aes = list(fill = NA)), fill = FALSE) +
labs(x = "",
y = "Estimated effective reproduction\nnumber (Re)") +
scale_colour_manual(values = pal)
R <- r_all_sliding_7days %>%
mutate(lower_95 = R_lower_95,
upper_95 = R_upper_95,
value = R,
measure = "R",
reference = 1)
r_R <- r_all_sliding_7days %>%
mutate(measure = "r",
value = r,
reference = 0) %>%
bind_rows(R)
r_R_7 <- r_R %>%
ggplot(aes(x = w_max, y = value)) +
geom_ribbon(aes(ymin = lower_95, ymax = upper_95, fill = nhs_region), alpha = 0.1) +
geom_line(aes(colour = nhs_region)) +
geom_point(aes(colour = nhs_region)) +
geom_hline(aes(yintercept = reference), linetype = "dashed") +
theme_bw() +
scale_weeks +
theme(legend.position = "bottom",
plot.margin = margin(0.5,1,0,0, "cm"),
strip.background = element_blank(),
strip.placement = "outside"
) +
guides(color = guide_legend(title = "", override.aes = list(fill = NA)), fill = FALSE) +
labs(x = "", y = "") +
scale_colour_manual(values = pal) +
facet_grid(rows = vars(measure),
scales = "free_y",
switch = "y",
labeller = as_labeller(c(r = "Daily growth rate (r)",
R = "Effective reproduction\nnumber (Re)")))Then with the 21 days window:
## set moving time window (1/2/3 weeks)
w <- 21
# create empty df
r_all_sliding_21days <- NULL
## make data for model
x_model_all_moving <- x %>%
filter(!is.na(nhs_region)) %>%
group_by(date, nhs_region) %>%
summarise(n = sum(count))
unique_dates <- unique(x_model_all_moving$date)
for (i in 1:(length(unique_dates) - w)) {
date_i <- unique_dates[i]
date_i_max <- date_i + w
model_data <- x_model_all_moving %>%
filter(date >= date_i & date < date_i_max) %>%
mutate(day = as.integer(date - date_i)) %>%
day_of_week()
mod <- glm(n ~ day * nhs_region + day_of_week,
data = model_data,
family = 'quasipoisson')
# get growth rate
r <- get_r(mod)
r$w_min <- date_i
r$w_max <- date_i_max
# combine all estimates
r_all_sliding_21days <- bind_rows(r_all_sliding_21days, r)
}
#serial interval distribution
SI_param = epitrix::gamma_mucv2shapescale(4.7, 2.9/4.7)
SI_distribution <- distcrete::distcrete("gamma", interval = 1,
shape = SI_param$shape,
scale = SI_param$scale,
w = 0.5)
#convert growth rates r to R0
r_all_sliding_21days <- r_all_sliding_21days %>%
mutate(R = epitrix::r2R0(r, SI_distribution),
R_lower_95 = epitrix::r2R0(lower_95, SI_distribution),
R_upper_95 = epitrix::r2R0(upper_95, SI_distribution))# plot
plot_growth <-
r_all_sliding_21days %>%
ggplot(aes(x = w_max, y = r)) +
geom_ribbon(aes(ymin = lower_95, ymax = upper_95, fill = nhs_region), alpha = 0.1) +
geom_line(aes(colour = nhs_region)) +
geom_point(aes(colour = nhs_region)) +
geom_hline(yintercept = 0, linetype = "dashed") +
theme_bw() +
scale_weeks +
theme(legend.position = "bottom",
plot.margin = margin(0.5,1,0.5,0.5, "cm")) +
guides(colour = guide_legend(title = "",override.aes = list(fill = NA)), fill = FALSE) +
labs(x = "",
y = "Estimated daily growth rate (r)") +
scale_colour_manual(values = pal)# plot
plot_R <-
r_all_sliding_21days %>%
ggplot(aes(x = w_max, y = R)) +
geom_ribbon(aes(ymin = R_lower_95, ymax = R_upper_95, fill = nhs_region), alpha = 0.1) +
geom_line(aes(colour = nhs_region)) +
geom_point(aes(colour = nhs_region)) +
geom_hline(yintercept = 1, linetype = "dashed") +
theme_bw() +
scale_weeks +
theme(legend.position = "bottom",
plot.margin = margin(0.5,1,0.5,0.5, "cm")) +
guides(color = guide_legend(title = "", override.aes = list(fill = NA)), fill = FALSE) +
labs(x = "",
y = "Estimated effective reproduction\nnumber (Re)") +
scale_colour_manual(values = pal)
R <- r_all_sliding_21days %>%
mutate(lower_95 = R_lower_95,
upper_95 = R_upper_95,
value = R,
measure = "R",
reference = 1)
r_R <- r_all_sliding_21days %>%
mutate(measure = "r",
value = r,
reference = 0) %>%
bind_rows(R)
r_R_21 <- r_R %>%
ggplot(aes(x = w_max, y = value)) +
geom_ribbon(aes(ymin = lower_95, ymax = upper_95, fill = nhs_region), alpha = 0.1) +
geom_line(aes(colour = nhs_region)) +
geom_point(aes(colour = nhs_region)) +
geom_hline(aes(yintercept = reference), linetype = "dashed") +
theme_bw() +
scale_weeks +
theme(legend.position = "bottom",
plot.margin = margin(0.5,1,0,0, "cm"),
strip.background = element_blank(),
strip.placement = "outside"
) +
guides(color = guide_legend(title = "", override.aes = list(fill = NA)), fill = FALSE) +
labs(x = "", y = "") +
scale_colour_manual(values = pal) +
facet_grid(rows = vars(measure),
scales = "free_y",
switch = "y",
labeller = as_labeller(c(r = "Daily growth rate (r)",
R = "Effective reproduction\nnumber (Re)")))And we combine both outputs into a single plot:
ggpubr::ggarrange(r_R_7,
r_R_21,
nrow = 2,
labels = "AUTO",
common.legend = TRUE,
legend = "bottom")
lag_cor_reg <- data.frame()
for (i in 0:30) {
summary <-
all_data %>%
group_by(nhs_region) %>%
mutate(note_lag = lag(count, i)) %>%
## calculate rank correlation and bootstrap CI for each region
group_modify(~getboot(.x)) %>%
mutate(lag = i)
lag_cor_reg <- bind_rows(lag_cor_reg, summary)
}
cor_vs_lag_reg <-
lag_cor_reg %>%
ggplot(aes(lag, r, col = nhs_region)) +
geom_hline(yintercept = 0, lty = "longdash") +
geom_ribbon(aes(ymin = r_low, ymax = r_hi, col = NULL, fill = nhs_region), alpha = 0.2) +
geom_point() +
geom_line() +
facet_wrap(~nhs_region) +
scale_color_manual(values = pal) +
scale_fill_manual(values = pal, guide = F) +
theme_bw() +
labs(x = "Lag between NHS pathways and death data (days)", y = "Pearson's correlation", col = "NHS region") +
theme(legend.position = "bottom") +
guides(color = guide_legend(override.aes = list(fill = NA)))
cor_vs_lag_regWe save the tables created during our analysis:
if (!dir.exists("excel_tables")) {
dir.create("excel_tables")
}
## list all tables, and loop over export
tables_to_export <- c("r_all_sliding", "lag_cor")
for (e in tables_to_export) {
rio::export(get(e),
file.path("excel_tables",
paste0(e, ".xlsx")))
}
## also export result from regression on lagged data
rio::export(lag_mod, file.path("excel_tables", "lag_mod.rds"))The following information documents the system on which the document was compiled.
This provides information on the operating system.
This provides information on the version of R used:
This provides information on the packages used:
sessionInfo()
## R version 4.0.2 (2020-06-22)
## Platform: x86_64-apple-darwin17.0 (64-bit)
## Running under: macOS Catalina 10.15.6
##
## Matrix products: default
## BLAS: /Library/Frameworks/R.framework/Versions/4.0/Resources/lib/libRblas.dylib
## LAPACK: /Library/Frameworks/R.framework/Versions/4.0/Resources/lib/libRlapack.dylib
##
## locale:
## [1] en_US.UTF-8/en_US.UTF-8/en_US.UTF-8/C/en_US.UTF-8/en_US.UTF-8
##
## attached base packages:
## [1] stats graphics grDevices utils datasets methods base
##
## other attached packages:
## [1] ggnewscale_0.4.1 ggpubr_0.4.0 lubridate_1.7.9
## [4] chngpt_2020.5-21 cyphr_1.1.0 DT_0.14
## [7] kableExtra_1.1.0 janitor_2.0.1 remotes_2.2.0
## [10] projections_0.5.1 earlyR_0.0.1 epitrix_0.2.2
## [13] distcrete_1.0.3 incidence_1.7.1 rio_0.5.16
## [16] reshape2_1.4.4 rvest_0.3.5 xml2_1.3.2
## [19] linelist_0.0.40.9000 forcats_0.5.0 stringr_1.4.0
## [22] dplyr_1.0.0 purrr_0.3.4 readr_1.3.1
## [25] tidyr_1.1.0 tibble_3.0.3 ggplot2_3.3.2
## [28] tidyverse_1.3.0 here_0.1 reportfactory_0.0.5
##
## loaded via a namespace (and not attached):
## [1] nlme_3.1-148 fs_1.4.2 webshot_0.5.2 httr_1.4.2
## [5] rprojroot_1.3-2 tools_4.0.2 backports_1.1.8 utf8_1.1.4
## [9] R6_2.4.1 mgcv_1.8-31 DBI_1.1.0 colorspace_1.4-1
## [13] withr_2.2.0 gridExtra_2.3 tidyselect_1.1.0 sodium_1.1
## [17] curl_4.3 compiler_4.0.2 cli_2.0.2 labeling_0.3
## [21] matchmaker_0.1.1 scales_1.1.1 digest_0.6.25 foreign_0.8-80
## [25] rmarkdown_2.3 pkgconfig_2.0.3 htmltools_0.5.0 dbplyr_1.4.4
## [29] htmlwidgets_1.5.1 rlang_0.4.7 readxl_1.3.1 rstudioapi_0.11
## [33] farver_2.0.3 generics_0.0.2 jsonlite_1.7.0 crosstalk_1.1.0.1
## [37] car_3.0-8 zip_2.0.4 magrittr_1.5 kyotil_2019.11-22
## [41] Matrix_1.2-18 Rcpp_1.0.5 munsell_0.5.0 fansi_0.4.1
## [45] viridis_0.5.1 abind_1.4-5 lifecycle_0.2.0 stringi_1.4.6
## [49] yaml_2.2.1 carData_3.0-4 snakecase_0.11.0 MASS_7.3-51.6
## [53] plyr_1.8.6 grid_4.0.2 blob_1.2.1 crayon_1.3.4
## [57] lattice_0.20-41 cowplot_1.0.0 splines_4.0.2 haven_2.3.1
## [61] hms_0.5.3 knitr_1.29 pillar_1.4.6 boot_1.3-25
## [65] ggsignif_0.6.0 reprex_0.3.0 glue_1.4.1 evaluate_0.14
## [69] data.table_1.12.8 modelr_0.1.8 vctrs_0.3.2 selectr_0.4-2
## [73] cellranger_1.1.0 gtable_0.3.0 assertthat_0.2.1 xfun_0.15
## [77] openxlsx_4.1.5 broom_0.7.0 rstatix_0.6.0 survival_3.1-12
## [81] viridisLite_0.3.0 ellipsis_0.3.1